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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Improving the organization and interactivity of metabolic pathfinding with precomputed pathways

Fig. 2

HPAT can recover three of seven pathways patented for use in the production of 3-hydroxypropionic acid (3-HP) starting from pyruvate. The seven pathways are numbered according to Jiang et al. [41]. Intermediates that are underlined represent hub compounds from the 50 in-degree (I) hub table (see Table 2 for details). Arrows represent reactions linking intermediates where the color of the arrow indicates if they are found by the HPAT search where at least one carbon is conserved. Solid green arrows represent reactions that were found by the HPAT search, solid orange arrows represent reactions that were not found in the search, dashed arrows are require multiple reactions, and an X marks those reactions that are absent from KEGG and cannot be found by the search, grey arrows represent alternative reactions found by the search but not associated with the seven pathways, and the green highlight represents entire pathways between pyruvate and 3-HP that are recovered. a Reactions identified in the HPAT search connecting TCA cycle intermediates, succinate, malate, and fumarate, to Pathways III and IV (b) and viable acetate and malonate to Pathway II (c)

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