Fig. 4
From: The corrected gene proximity map for analyzing the 3D genome organization using Hi-C data
Gene set tightness for two groups of genes in GM12878 and K562 cell lines. The first group contains 100 most up-regulated genes in GM12878 as compared with K562 whereas the second group consists of 100 most down-regulated genes. From left to right, the gene set tightness is computed from the CGP map (B) and the gene proximity map (W), respectively. In both panels, the blue and yellow bars represent GM12878 and K562 cell lines, respectively. The gene set tightness quantifies to what extent a set of genes are spatially close together in the cell nucleus. A high tightness means the genes are spatially in closer proximity than expectation whereas a low tightness implies that genes are far apart