Fig. 5
From: The corrected gene proximity map for analyzing the 3D genome organization using Hi-C data
(Outset) Pathway tightness change, from cell lines GM12878 to K562, for all 186 metabolic pathways in the KEGG database. From top to bottom the pathways are sorted according to the tightness change computed from the CGP. The red bars represent the 17 pathways found to be statistically enriched with differentially expressed genes (up-regulated) in GM12878 with respect to K562. The horizontal axis shows the pathway tightness change. A negative value indicates that the pathway genes are in closer proximity in GM12878 but far apart in K562. A positive difference means the opposite. (Inset) Names and pathway tightness change of the 17 statistically enriched pathways. From top to bottom the pathways are ranked according to the tightness change computed from the CGP (red bars). The yellow bars represent the tightness change computed from the gene proximity map. The horizontal axis is the same as that in the outset