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Fig. 6 | BMC Bioinformatics

Fig. 6

From: The corrected gene proximity map for analyzing the 3D genome organization using Hi-C data

Fig. 6

Change in relative spatial positioning of chromosomes between GM12878 and K562 cell lines. The 23 nodes correspond to 23 chromosomes. The node size is proportional to the number of genes in the chromosome. Weighted blue and red links illustrate the extent and direction of proximity changes. The thickness and color of an edge between nodes i and j represent the magnitude and sign of the inter-chromosomal corrected proximity difference from GM12878 to K562. A thick blue (red) edge means that the inter-chromosomal proximity is substantially smaller (greater) in K562 as compared with GM12878. The network is fully connected, many edges are not shown because their weights (change in corrected proximity) are too small

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