Fig. 4
From: Exact solving and sensitivity analysis of stochastic continuous time Boolean models
Effect of one-dimensional parameter scan on the stationary probability (y axis) of the Apoptosis node of the breast cancer model[39]. The stationary probability value of the Apoptosis node is plotted as a function of the transition rates in the legends. Only transition rates where the variation of at least one node’s stationary value is larger than 0.1 are shown. The three panels show the model’s behavior under 3 different settings of the input nodes: the drugs Alpelisib and Everolimus and the node PIM (PIM protein family), abbreviated [Alp,Ev,PIM]. The values [110],[010],[100] above the panels show the values of these three nodes. Under double inhibition, shown on the top panel, the model has a single attractor state with Apoptosis=1, irrespective of the value of transition rates