Fig. 2From: SCSIM: Jointly simulating correlated single-cell and bulk next-generation DNA sequencing dataGraphical model representation of the SCSIM hierarchical model. To generate data from the model, first, sample a distribution over K mutant genomes, G″. Sample a distribution for each biological unit (individual), Gi′ for i=1,…,N. Sample a distribution for each sample (biopsy), Gij′ for j=1,…,Ni. Sample variant locations and types that define the mutant synthetic genomes H=[h1,…,hK]. Finally, sample the bulk and single-cell reads for each sample XijBack to article page