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Fig. 2 | BMC Bioinformatics

Fig. 2

From: SCSIM: Jointly simulating correlated single-cell and bulk next-generation DNA sequencing data

Fig. 2

Graphical model representation of the SCSIM hierarchical model. To generate data from the model, first, sample a distribution over K mutant genomes, G″. Sample a distribution for each biological unit (individual), Gi′ for i=1,…,N. Sample a distribution for each sample (biopsy), Gij′ for j=1,…,Ni. Sample variant locations and types that define the mutant synthetic genomes H=[h1,…,hK]. Finally, sample the bulk and single-cell reads for each sample Xij

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