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Fig. 4 | BMC Bioinformatics

Fig. 4

From: ARTDeco: automatic readthrough transcription detection

Fig. 4

Read-in genes mainly contribute noise to downstream functional analysis of differentially regulated genes. a Volcano plot of DESeq2 results for the maximum expressed isoform for each gene from IAV-infected macrophages vs. Mock-infected controls. Genes were considered up- or down-regulated if they had |log2 fold change| > 2 and adjusted p-value < 0.05 as well as FPKM > 0.25. b Heat map of GO enrichment (−log10 p-value) for top 15 GO terms in primary induction and read-in genes. c Bar chart of proportion of genes from each gene list in a given GO term for top 10 GO terms for primary induction genes, read-in genes, all upregulated genes, and random 500 genes with expression > 0.25 FPKM. d HOMER motif enrichments (q-value) for top 3 known motifs in primary induction genes

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