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Fig. 7 | BMC Bioinformatics

Fig. 7

From: Proteus: An algorithm for proposing stabilizing mutation pairs based on interactions observed in known protein 3D structures

Fig. 7

Proteus complete pipeline. Structural alignment has a high computational cost. Hence, we used a filter step to reduce the number of structural alignments. The filter step uses the variation of structural signatures (fingerprints) to remove structures from ProteusDB with a low possibility to be like target triad pairs. SSV (structural signature variation) uses Euclidean distance between four-dimensional vectors, which has lower computational cost than structural alignment. This accelerates the search for similar structures considerably

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