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Table 1 Proteus’ results for the first case study (details were included in the supplementary material: Tables S2, S3, S4, S5). (1) β-glucosidase project is available at: http://proteus.dcc.ufmg.br/result/id/4L8HLU. (2) Protease project is available at: http://proteus.dcc.ufmg.br/result/id/N7Q9RZ. (3) Immunoglobulin new antigen receptor project is available at: http://proteus.dcc.ufmg.br/result/id/UM6SQD. (4) Lipase project is available at: http://proteus.dcc.ufmg.br/result/id/YTP3YC

From: Proteus: An algorithm for proposing stabilizing mutation pairs based on interactions observed in known protein 3D structures

#

Protein

PDB ID

ProteusID

Sequence length

Number of mutations suggested

1

β-glucosidase (hydrolase)

1BGA

4L8HLU

447

344

2

Protease

1LVB

N7Q9RZ

243

61

3

Immunoglobulin new antigen receptor

2YWY

UM6SQD

113

50

4

Lipase

1LGY

YTP3YC

269

213