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Table 2 The overall accuracy of mutants that present a higher number of contacts or at least keep the number of contacts when compared to the wild type (details were included in the supplementary material: Tables S7, S8, S9, S10)

From: Proteus: An algorithm for proposing stabilizing mutation pairs based on interactions observed in known protein 3D structures

Proteus ID PDB ID HB Weak HB Ionic Aromatic Polar Weak polar Hydrophobic1
UM6SQD 2YWY 0.84 0.66 0.962 0.842 0.94 0.98 0.28
N7Q9RZ 1LVB 0.97 0.79 1.0 0.9 0.95 1.0 0.26
YTP3YC 1LGY 0.77 0.662 0.982 0.9 0.96 1.0 0.31
4L8HLU 1BGA 0.79 0.42 0.84 0.772 0.87 0.98 0.22
  1. 1For hydrophobic interactions, we also calculated the accuracy considering mutant structures that reduced or kept the number of contacts. For this case, UM6SQD presented an accuracy of 0.84; N7Q9RZ of 0.82; YTP3YC of 0.86; and 4L8HLU of 0.88. 2 Not statistically relevant (check supplementary material for details). HB: hydrogen bonds. The projects are available at http://proteus.dcc.ufmg.br/result/id/[Proteus ID]