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Fig. 5 | BMC Bioinformatics

Fig. 5

From: PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients

Fig. 5

PDXGEM for 5FU response prediction in colorectal cancer patients. a Distribution of PDXGEM scores (Y-axis) between responsive and non-responsive patients after at a treatment with 5FU-based chemotherapy. b-d Kaplan-Meier curves of overall survival for the high (dotted gray), intermediate (gray), and low (black) score group in (b) primary colorectal cancer (CRC) patients receiving 5-FU monotherapy in GSE39581 (c), and metastatic CRC patients receiving FOLFIRI monotherapy in GSE39581 (d) and primary CRC patients receiving FOLFIRI in GSE39581. Prediction scores were broken down at their tertiles. The P value was calculated using a survival trend test. e Distribution of PDXGEM scores (y-axis) of CRC patients who did not received 5-FU. The P value was calculated using Tarone’s trend test

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BMC Bioinformatics

ISSN: 1471-2105

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