iPNHOT: a knowledge-based approach for identifying protein-nucleic acid interaction hot spots

BMC Bioinformatics

Table 4 Comparison with mCSM-NA on both the training data set and the independent test set

Datasets	Methods	REC	PRE	SPE	ACC	F1 score	MCC
Training dataset	mCSM-NA	0.419	0.356	0.686	0.608	0.385	0.100
Training dataset	iPNHOT	0.628	0.750	0.913	0.829	0.684	0.572
Training dataset (ProNIT)^a	mCSM-NA	0.297	0.647	0.907	0.686	0.407	0.264
Training dataset (ProNIT)^a	iPNHOT	0.676	0.781	0.892	0.814	0.725	0.589
Independent test set	mCSM-NA	0.571	0.163	0.627	0.621	0.254	0.129
Independent test set	iPNHOT	0.571	0.320	0.845	0.815	0.410	0.329

^aThe subset of the training data set which includes 102 residues collected from ProNIT

ISSN: 1471-2105