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Table 5 The synthetic repurposing of drugs for the HT

From: Synthetic repurposing of drugs against hypertension: a datamining method based on association rules and a novel discrete algorithm

HT drug The selected drugs by the algorithms
Trader WCC CUK FOA DSOS
Trandolapril Cilazapril Enalapril Fosinopril Fosinopril Quinapril
Atenolol Esmolol Esmolol Alprenolol Nebivolol Practolol
Carteolol (Xamoterol+Nebivolol) (Xamoterol+Nebivolol) Penbutolol Penbutolol Penbutolol
Nicardipine (Cyclandelate+Nisoldipine), (Drotaverine+Nisoldipine) (Drotaverine+Nisoldipine) (Drotaverine+Nisoldipine)
Felodipine (Pinaverium+ Nisoldipine) (Pinaverium+Nilvadipine) (Pinaverium+Mibefradil) (Pinaverium+Nifedipine) (Pinaverium+Nilvadipine)
Nifedipine (Pinaverium + Nisoldipine)
Nisoldipine (Pinaverium+Isradipine), (Pinaverium+Drotaverine+Nilvadipine)
Doxazosin (Nicergoline) (Droperidol) (Dapiprazole)
Prazosin (Dapiprazole), (Nicergoline+Tamsulosin),
(Nicergoline+Periciazine+Dapiprazole)
(Alfuzosin+Flupentixol) (Alfuzosin+Flupentixol) (Alfuzosin+Phentolamine) (Alfuzosin+Silodosin)
  1. WCC World competitive contest algorithm, CUK Cuckoo, FOA Forest optimization algorithm, DSOS Discrete symbiotic optimization search