Fig. 11
An objective function enables principled optimization of the signature threshold. a hROC for the MOA signature with mtop = 35, showing origin of factors discussed in connection with Eq.(16) in A. The short black bar labeled “C” refers to the treatment cost, and the bar labeled “B” to the treatment benefit terms entering into Eq.(14). b Optimization of the objective function φ(q) occurs for q∗ = 0.4 (vertical dashed line). The corresponding threshold is ∆ξc = − 0.73, with hazard ratios hR(S) = 0.28 and hR(R) = 1.22