Fig. 7
The Patient Selection Matrix is a summary of prognostic and predictive powers of the signature. a The Patient Selection Matrix (PSM) (shown for the 5-fold cross-validated subC-LP signature) is built around the 2 × 2 contingency table of outcomes according to {treatment arm × response group} classification of the patients (here for decision threshold ∆ξc = − 0.815). The cells in the core of the table (grey) contain median survival times (months) for each category of the classification. Margins labeled n, hR and pR indicate the total number of subjects, hazard ratio, and attendant P-value, respectively, arising from differential survival analysis along the corresponding rows or columns. b Number of patients in each {treatment arm × response group} category. c KM plot for the n = 109 patients in the relatively-resistant group and d, KM plot for the n = 100 patients in the sensitive group