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Fig. 2 | BMC Bioinformatics

Fig. 2

From: An integrative network-driven pipeline for systematic identification of lncRNA-associated regulatory network motifs in metastatic melanoma

Fig. 2

Interaction network of lncRNA, miRNA, and TF in melanoma. Each rectangular node (peach color) indicates lncRNAs which acting as miRNA sponges and affect proteins. Each octagon node (yellow color) indicates experimentally validated TFs which regulate (activation or repression) miRNAs. The network shows miRNAs (rectangular node, cyan color) that negatively regulates the expression of target genes, and it also includes interactions between TFs. The network comprises 174 nodes, including melanoma-associated lncRNAs (17), miRNAs (132), and TFs (25). Network edges (total 655) are colored by the type of interaction between the nodes which are as follows: T bar-shaped edge for functional MTI (light blue color), repression (dark green color), down-regulation (black color); broadhead shaped-arrow for activation (purple color), up-regulation (black color), regulation (purple color); and an undirected edge for binding (fluorescent green color)

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