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Fig. 6 | BMC Bioinformatics

Fig. 6

From: METROID: an automated method for robust quantification of subcellular fluorescence events at low SNR

Fig. 6

Experimental VSD imaging real data application. a Bright-field isolated cardiomyocyte image overlaid by one ROI. b ROI means photobleaching correction for AP experiment (left graphic) and electroporation experiment (right graphic). Gray continuous lines are ROI means over time, dark blue or dark green dots are photobleaching correction input data, dashed light blue line (left graphic) is Double Bind Photobleaching Correction (DBPC), dashed light green line (right graphic) is Full Data Photobleaching Correction (FDPC), and dot-dashed green line is FDPC without step. c Blind source separation application after photobleaching correction for AP (left graphic) and electroporation (right graphic) experiments. Gray continuous line are ROI means fixed for photobleaching, thick blue continuous line (left graphic) is ICA output, light blue dashed line is wICA output, thick dark red continuous line is PCA output (right graphic), and orange dashed line is wPCA output. Estimated signal-to-noise ratios (SNR) are shown above each graphic

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