Table 7 Top 5 Interactions predicted by DTIP_MDHN on the benchmark datasets
From: Drug-target interactions prediction using marginalized denoising model on heterogeneous networks
Dataset | KEGG Drug ID | Drug name | KEGG Has ID | Uniport ID | Gene name | Validated |
|---|---|---|---|---|---|---|
Enzyme | D00542 | Halothane | has:1571 | P05181 | CYP2E1 | Yes |
D00139 | Methoxsalen | has:1543 | P04798 | CYP1A1 | Yes | |
D00437 | Nifedipine | has:1559 | P11712 | CYP2C9 | Yes | |
D00410 | Metyrapone | has:1543 | P04798 | CYP1A1 | Yes | |
D00574 | Aminoglutethimide | has:1589 | P08686 | CYP21A2 | Yes | |
Ion Channel | D03365 | Nicotine | has:1137 | P43681 | CHRNA4 | Yes |
D00640 | Propafenone hydrochloride | has:6336 | Q9Y5Y9 | SCN10A | Yes | |
D02098 | Proparacaine hydrochloride | has:8645 | O95279 | KCNK5 | No | |
D02356 | Verapamil | has:2893 | P48058 | GRIA4 | No | |
D00552 | Benzocaine | has:6331 | Q14524 | SCN5A | Yes | |
GPCR | D00683 | Albuterol sulfate | has:153 | P08588 | ADRB1 | Yes |
D02359 | Ritodrine | has:153 | P08588 | ADRB1 | No | |
D02147 | Albuterol | has:153 | P08588 | ADRB1 | Yes | |
D01386 | Ephedrine hydrochloride | has:153 | P08588 | ADRB1 | Yes | |
D00604 | Clonidine hydrochloride | has:148 | P35348 | ADRA1A | No | |
Nuclear Receptor | D00316 | Etretinate | has:6096 | Q58EY0 | RORβ | No |
D01132 | Tazarotene | has:6097 | P51449 | RORγ | No | |
D00182 | Norethindrone | has:2099 | P03372 | ESR1 | Yes | |
D00348 | Isotretinoin | has: 5915 | P10826 | RARB | Yes | |
D01115 | Eplerenone | has:2908 | P04150 | NR3C1 | No |