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Fig. 2 | BMC Bioinformatics

Fig. 2

From: NPF:network propagation for protein function prediction

Fig. 2

Flowchart of NPF method. a Three protein correlation networks Co_Neighbor, Co-Domain and Co-Complex are derived from original PIN, protein domain data, as well as protein complex information, respectively. b The propagation network PN is generated by running an improved random walk with restart algorithm on multiple functional similarity networks. The propagation process is illustrated at different steps until convergence. Changes in the color of nodes in the graph indicate the progress of the iterative process. c Annotation for target proteins. Taking the target node as the seed node, a highly cohesive functional module can be obtained. Functions of neighbors in the detected functional module are used to characterize the target node

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