Novel domain expansion methods to improve the computational efficiency of the Chemical Master Equation solution for large biological networks

Table 5 Comparison of the solution of the catalytic reaction system based on ISP, OFSP and SSA

t_f = 0.5, t_step = 0.01	*ISP*		*OFSP*	*SSA*
t_f = 0.5, t_step = 0.01	*LAS*	*LOLAS*	*OFSP*	*SSA*
Catalytic reaction system (t_f = 0.5, t_step = 0.01)
Run-time (sec)	4677	2706	8767	17428
Domain at t_f	14666	13089	14665	10⁶ Runs
Expansion time	0.5	0.5	0.5	-
Error at t_f	1.865e − 05	1.532e − 05	1.917e − 05	≈9.81 x 10⁻³
Dual enzymatic reaction system (t_f = 2.0, t_step = 0.01)
Run-time (sec)	2386	1614	2804	6374
Domain at t_f	8282	8296	8266	10⁵ Runs
Expansion time	2.0	2.0	2.0	-
Error at t_f	7.470e − 05	5.953e − 05	1.060e − 04	≈9.94 x 10⁻³

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