TY - JOUR AU - Bulathsinghalage, Chanaka AU - Liu, Lu PY - 2020 DA - 2020/09/30 TI - Network-based method for regions with statistically frequent interchromosomal interactions at single-cell resolution JO - BMC Bioinformatics SP - 369 VL - 21 IS - 14 AB - Chromosome conformation capture-based methods, especially Hi-C, enable scientists to detect genome-wide chromatin interactions and study the spatial organization of chromatin, which plays important roles in gene expression regulation, DNA replication and repair etc. Thus, developing computational methods to unravel patterns behind the data becomes critical. Existing computational methods focus on intrachromosomal interactions and ignore interchromosomal interactions partly because there is no prior knowledge for interchromosomal interactions and the frequency of interchromosomal interactions is much lower while the search space is much larger. With the development of single-cell technologies, the advent of single-cell Hi-C makes interrogating the spatial structure of chromatin at single-cell resolution possible. It also brings a new type of frequency information, the number of single cells with chromatin interactions between two disjoint chromosome regions. SN - 1471-2105 UR - https://doi.org/10.1186/s12859-020-03689-x DO - 10.1186/s12859-020-03689-x ID - Bulathsinghalage2020 ER -