Fig. 2

Network analysis of ImmunoGlobe recapitulates known features of the immune system. a A visualization of the ImmunoGlobe immune interaction network, with immune cells organized by hematopoietic lineage and other nodes grouped according to node type. Interactions between the nodes are shown as colored edges. b A legend showing the shapes representing each node type. c A legend showing the line shapes representing each edge type. d Summary characteristics of the immune interaction network. Number of nodes and edges are shown, and density, average path length throughout the network, and diameter of the network were calculated. e A pie chart showing the counts of each node type. f A bar graph showing the number of directional edges between different node types. The majority of interactions are between cells and cytokines. g Visualization of the number of edges between all node types. Each chord represents one directional interaction and is colored by node type of the source node. h Histograms showing the total degree distribution of each node type in the network. Each count on the Y axis represents one node. For all node types, the degree distributions skew right. i A scatter plot showing the in and out degrees of various cytokines. Points are colored by the number of cytokines with that combination of in- and out-degree. Cytokines with higher degrees are labeled. j A bar plot showing the degrees of various cell types. The height of the bar represents the total degree, with in and out degrees shown by fill color