Fig. 3
From: SQMtools: automated processing and visual analysis of ’omics data with R and anvi’o
Detailed overview of the biosynthesis of aromatic amino acids. a KEGG pathway map for Phenylalanine, Tyrosine and Tryptophan biosynthesis. Reactions are coloured based on the log2 fold-change of their average copy numbers in Italian (orange) vs Hadza (blue) samples. Asterisks indicated reactions performed by KEGG orthologs that were significantly enriched in Hadza (blue) or Italian (orange) samples (DESeq2 p adj. < 0.05). Black asterisks indicate reactions in which a different KEGG ortholog was enriched in Hadza and Italian samples (note that the same reaction can be performed by more than one KEGG ortholog). Asterisks within parentheses indicate reactions in which some, but not all KEGG orthologs were significantly enriched in a group. b anvi’o plot showing the taxonomy and distribution across samples of the contigs containing genes related to the biosynthesis of aromatic amino acids. c Heatmap depicting the TPM across samples of selected KEGG orthologs related to the biosynthesis of aromatic amino acids. Asterisks indicate significant enrichment in Hadza or Italian samples as described above