Fig. 3

a For each virus protein, a clique was made by all of its HPs’ targets. Connectivity of the human nodes targeted by the same virus node (CHTV) is the number of interactions between the elements of the clique in human protein-protein interaction network (HPPIN) (pink lines) divided by number of clique edges (blue lines). In this example, CHTV will be 0.3. b Propagation Speed (PS) illustrates the percentage of infected human proteins (HPs) in three levels. At each level, PS is the Sum of the number of infected HPs up to that level and their neighbors divided by the number of all HPs. By assuming yellow node labeled by S as the first infected human protein, green nodes are the first group of human proteins which will be infected by S, thus PS1 score is 0.3 and 0.2 for the first and second networks, respectively. The blue nodes will be infected by the green nodes while the orange nodes will be infected by blue nodes