Fig. 4From: Joint pre-processing framework for two-dimensional gel electrophoresis images based on nonlinear filtering, background correction and normalization techniquesSynthetic protein spots modelled as a 2-D Gaussian distribution with background. a Example of a synthetic image. b Synthetic image with background correction using thresholding. c Synthetic image with background correction using multilevel thresholding. d Synthetic image with background correction using surface approximationBack to article page