Table 7 The common target of drugs and their alternative herbs

Milnacipran

Sodium-dependent serotonin transporter

桃仁(beta-sitosterol), 紫苏(beta-sitosterol), 红花(beta-sitosterol), 夏枯草(beta-sitosterol) 乌药(beta-sitosterol, Boldine), 藿香(5-Hydroxy-7,4′-dimethoxyflavanon)

Sodium-dependent noradrenaline transporter

桃仁(2,3-didehydro GA70, hederagenin,), 红花(kaempferol, Stigmasterol), 夏枯草(kaempferol, Stigmasterol), 熟地黄(Stigmasterol)

Mianserin

Alpha-2A adrenergic receptor

红花(Stigmasterol), 三七(Stigmasterol), 丹参(4-methylenemiltirone,salviolone)

Sodium-dependent noradrenaline transporter

桃仁(2,3-didehydro GA70, hederagenin), 红花(kaempferol, Stigmasterol), 白芍(kaempferol), 三七(Stigmasterol)

Sodium-dependent serotonin transporter

桃仁(beta-sitosterol), 紫苏(beta-sitosterol), 红花(beta-sitosterol), 乌药(beta-sitosterol, Boldine)

白芍(beta-sitosterol), 藿香(5-Hydroxy-7,4′-dimethoxyflavanon), 丹参(1,2,5,6-tetrahydrotanshinone, 2-isopropyl-8-methylphenanthrene-3,4-dione, 4-methylenemiltirone, Methylenetanshinquinone, danshenspiroketallactone, Dihydrotanshinlactone, Epidanshenspiroketallactone, neocryptotanshinone ii,salviolone)

Alpha-2C adrenergic receptor

丹参(4-methylenemiltirone, Miltirone,), 乌药(6,7-dimethoxy-2-(2-phenylethyl)chromone, DMPEC)

Alpha-2B adrenergic receptor

丹参(salviolone)

Sodium-dependent dopamine transporter

红花(Stigmasterol), 丹参(1,2,5,6-tetrahydrotanshinone, 2-isopropyl-8-methylphenanthrene-3,4-dione,4-methylenemiltirone,dihydrotanshinlactone, Miltirone, neocryptotanshinone ii, salviolone), 乌药(6,7-dimethoxy-2-(2-phenylethyl)chromone, DMPEC,

Boldine)

Trazodone

Sodium-dependent serotonin transporter

桃仁(beta-sitosterol), 紫苏(beta-sitosterol), 红花(beta-sitosterol), 乌药(beta-sitosterol, Boldine)

藿香(5-Hydroxy-7,4′-dimethoxyflavanon), 丹参(1,2,5,6-tetrahydrotanshinone, 2-isopropyl-8-methylphenanthrene-3,4-dione, 4-methylenemiltirone, Methylenetanshinquinone, danshenspiroketallactone, Dihydrotanshinlactone, Epidanshenspiroketallactone, neocryptotanshinone ii,salviolone)

Alpha-1A adrenergic receptor

桃仁(gibberellin 7), 红花(Stigmasterol), 丹参(1,2,5,6-tetrahydrotanshinone, sugiol, Dehydrotanshinone II A, 5,6-dihydroxy-7-isopropyl-1,1-dimethyl-2,3, 2-isopropyl-8-methylphenanthrene-3,4-dione,4-methylenemiltirone, 3-beta-Hydroxymethyllenetanshiquinone,Methylenetanshinquinone, przewaquinone c, cryptotanshinone, danshenspiroketallactone, deoxyneocryptotanshinone, dihydrotanshinlactone, dihydrotanshinoneI, epidanshenspiroketallactone, C09092, isocryptotanshi-none, Isotanshinone II, miltionone I, Miltirone, neocryptotanshinone ii, 1-methyl-8,9-dihydro-7H-naphtho[5,6-g]benzofuran-6,10,11-trione, salviolone, tanshinone iia, (6S)-6-(hydroxymethyl)-1,6-dimethyl-8,9-dihydro-7H-naphtho[8,7-g]benzofuran-10,11-dione,)

Alpha-2A adrenergic receptor

红花(Stigmasterol), 丹参(4-methylenemiltirone,salviolone)

Nortriptyline

Sodium-dependent noradrenaline transporter

桃仁(2,3-didehydro GA70, hederagenin,), 红花(kaempferol, Stigmasterol), 白芍(kaempferol)

Sodium-dependent serotonin transporter

桃仁(beta-sitosterol), 紫苏(beta-sitosterol), 红花(beta-sitosterol), 白芍(beta-sitosterol), 藿香(5-Hydroxy-7,4′-dimethoxyflavanon), 丹参(1,2,5,6-tetrahydrotanshinone, 2-isopropyl-8-methylphenanthrene-3,4-dione, 4-methylenemiltirone, Methylenetanshinquinone, danshenspiroketallactone, Dihydrotanshinlactone, Epidanshenspiroketallactone, neocryptotanshinone ii,salviolone)

Alpha-1A adrenergic receptor

桃仁(gibberellin 7), 红花(Stigmasterol), 熟地黄(Stigmasterol), 丹参(1,2,5,6-tetrahydrotanshinone, sugiol, Dehydrotanshinone II A, 5,6-dihydroxy-7-isopropyl-1,1-dimethyl-2,3, 2-isopropyl-8-methylphenanthrene-3,4-dione,4-methylenemiltirone, 3-beta-Hydroxymethyllenetanshiquinone,Methylenetanshinquinone, przewaquinone c, cryptotanshinone, danshenspiroketallactone, deoxyneocryptotanshinone, dihydrotanshinlactone, dihydrotanshinoneI, epidanshenspiroketallactone, C09092, isocryptotanshi-none, Isotanshinone II, miltionone I, Miltirone, neocryptotanshinone ii, 1-methyl-8,9-dihydro-7H-naphtho[5,6-g]benzofuran-6,10,11-trione, salviolone, tanshinone iia, (6S)-6-(hydroxymethyl)-1,6-dimethyl-8,9-dihydro-7H-naphtho[8,7-g]benzofuran-10,11-dione,)

Alpha-1D adrenergic receptor

丹参(1,2,5,6-tetrahydrotanshinone,Sugiol,2-isopropyl-8-methylphenanthrene-3,4-dione, 4-methylenemiltirone, cryptotanshinone, danshenspiroketallactone, neocryptotanshinone,)

乌药(Norboldine,Boldine)

Duloxetine

Sodium-dependent serotonin transporter

桃仁(beta-sitosterol), 紫苏(beta-sitosterol), 红花(beta-sitosterol), 乌药(beta-sitosterol, Boldine)

赤芍(beta-sitosterol), 藿香(5-Hydroxy-7,4′-dimethoxyflavanon), 丹参(1,2,5,6-tetrahydrotanshinone, 2-isopropyl-8-methylphenanthrene-3,4-dione, 4-methylenemiltirone, Methylenetanshinquinone, danshenspiroketallactone, Dihydrotanshinlactone, Epidanshenspiroketallactone, neocryptotanshinone ii,salviolone)

Sodium-dependent noradrenaline transporter

桃仁(2,3-didehydro GA70, hederagenin,), 红花(kaempferol, Stigmasterol), 熟地黄(Stigmasterol), 三七(Stigmasterol), 赤芍(Stigmasterol)

Sodium-dependent dopamine transporter

红花(Stigmasterol), 熟地黄(Stigmasterol), 赤芍(Stigmasterol), 丹参(1,2,5,6-tetrahydrotanshinone, 2-isopropyl-8-methylphenanthrene-3,4-dione,4-methylenemiltirone,dihydrotanshinlactone, Miltirone, neocryptotanshinone ii, salviolone), 乌药(6,7-dimethoxy-2-(2-phenylethyl)chromone, DMPEC,Boldine)

Clomipramine

Sodium-dependent serotonin transporter

桃仁(beta-sitosterol), 紫苏(beta-sitosterol), 红花(beta-sitosterol), 夏枯草(beta-sitosterol), 乌药(beta-sitosterol, Boldine), 黄柏(beta-sitosterol, Cavidine, Fumarine, Isocorypalmine, (S)-Canadine), 白芍(beta-sitosterol), 藿香(5-Hydroxy-7,4′-dimethoxyflavanon), 丹参(1,2,5,6-tetrahydrotanshinone, 2-isopropyl-8-methylphenanthrene-3,4-dione, 4-methylenemiltirone, Methylenetanshinquinone, danshenspiroketallactone, Dihydrotanshinlactone, Epidanshenspiroketallactone, neocryptotanshinone ii,salviolone)

Sodium-dependent noradrenaline transporter

桃仁(2,3-didehydro GA70, hederagenin,), 红花(kaempferol, Stigmasterol), 白芍(kaempferol), 熟地黄(Stigmasterol)

Glutathione S-transferase P

藿香(quercetin), 红花(quercetin, luteolin, kaempferol), 乌药(quercetin), 紫苏(luteolin), 丹参(luteolin), 白芍(kaempferol)