Skip to main content
Fig. 2 | BMC Bioinformatics

Fig. 2

From: MEIRLOP: improving score-based motif enrichment by incorporating sequence bias covariates

Fig. 2

Logistic regression with covariates recovers motifs mediating IFN-β stimulation response in differentially acetylated ChIP-seq peaks. a Ranks of the motif enrichment scores for motifs bound by TFs activated by IFN-β across score-based MEA methods. Higher percentile ranks indicate the motif considered more significantly enriched relative to other motifs in the results of each method. Motifs excluded from enrichment reports are assigned a rank of 0. b Reproducibility of logistic regression accuracy of MEIRLOP when calling enrichment of the STAT1::STAT2 binding motif, with and without controlling for dinucleotide frequency covariates. Each point represents enrichment results on a bootstrap sample of the same dataset. c Swarm plot depicting the distributions of score ranks for peaks with and without STAT1::STAT2 binding motif instances. Each point represents a scored peak

Back to article page