Fig. 4

a Effect of the mediator genes essential for normal brain functioning on the downstream genes. The forest plot represents 95% confidence intervals of the effect size in downstream gene transcription by the different mediator gene, red: mean effect size for SCZ-cases, blue: mean effect size for controls. Non-significant effect corresponds to loss of mediators. b Upstream genes and downstream genes for the mediators (ZNF672, ZNF692, SORT1, SNRNP48, GNAL, RALGPS2) and their causal effects. The arrows represent transcription activation (positive effect size). The line with capped end represents transcriptional repression (negative effect size). In cyan there are the genes reported as associated with SCZ in previous studies. For all interactions, the effect size (Est) and standard deviation (Std) are shown