Differential gene regulatory pattern in the human brain from schizophrenia using transcriptomic-causal network

BMC Bioinformatics

Table 2 Results of overrepresentation analysis for the enriched Novel SCZ associated genes

Enrichment	Pathway description	p-value	p. adjust	Gene symbol
KEGG	FoxO signaling pathway	0.0324	0.0445	FBXO32
KEGG	Axon guidance	0.0446	0.0446	UNC5D
GO	protein phosphorylated amino acid binding	0.0115	0.0319	RTF1
GO	RNA polymerase II complex binding	0.0119	0.0319	RTF1
GO	RNA polymerase core enzyme binding	0.0137	0.0319	RTF1
GO	basal transcription machinery binding	0.0162	0.0319	RTF1
GO	basal RNA polymerase II transcription machinery binding	0.0163	0.0319	RTF1
GO	RNA polymerase binding	0.0171	0.0319	RTF1
GO	phosphoprotein binding	0.0186	0.0319	RTF1
GO	single-stranded DNA binding	0.0253	0.0380	RTF1
Reactome	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes	0.0081	0.0323	FBXO32
Reactome	Netrin-1 signaling	0.0140	0.0323	UNC5D
Reactome	E3 ubiquitin ligases ubiquitinate target proteins	0.0165	0.0323	RTF1
Reactome	Formation of RNA Pol II elongation complex	0.0171	0.0323	RTF1
Reactome	RNA Polymerase II Transcription Elongation	0.0171	0.0323	RTF1
Reactome	FOXO-mediated transcription	0.0182	0.0323	FBXO32
Reactome	Protein ubiquitination	0.0221	0.0323	RTF1
Reactome	RNA Polymerase II Pre-transcription Events	0.0234	0.0323	RTF1
DO	lateral sclerosis	0.0275	0.0813	FBXO32
DO	amyotrophic lateral sclerosis	0.0383	0.0813	FBXO32
DO	motor neuron disease	0.0462	0.0813	FBXO32
DO	chronic obstructive pulmonary disease	0.0542	0.0813	FBXO32
DO	obstructive lung disease	0.0755	0.0905	FBXO32

ISSN: 1471-2105