Fig. 3
Predicted ProNA-binding interface SAVs differed between human tissues. The sketches capture to which extent SAVs at residues predicted in the interfaces of protein-binding (left column), DNA-binding (middle column), or RNA-binding (right column) were over-represented in particular human tissue types (taken from HPA, the Human Protein Atlas [24]). Top row: common SAVs (> 5% of population); bottom row: rare SAVs (< 1% of population; note non-extremes between 1 and 5% were ignored). The values in each tissue were calculated as: (PERCtissue-PERCoverall)/PERCoverall (Methods). Values around 0 (white) represented observations as expected by chance, values < 0 (yellow) indicated under-representation, and values > 0 (red) over-representation. For instance, common SAVs predicted in DNA-binding interfaces were under-represented in lung tissue, but over-represented in the skin