Fig. 2
From: Moving forward through the in silico modeling of tuberculosis: a further step with UISS-TB
Outcome of digital patients treated with INH. Green line shows the average trend of the considered cellular entities. The orange shaded area represents their standard deviation (SD + /−). a Depicts the dynamics of AM before and after the administration of INH; the antibiotic, administered accordingly to the clinical trial protocol, reveals a not negligible biological restore of the damaged AM. b The dynamics of CD8 T cells. d The dynamics of TH17 cells responding to bacterial infection. c and e show flat curves because INH is not supposed to stimulate immune response. Simulation time has been set to 365 days (1 years) and digital patients have been challenged with MTB at day 15