Fig. 4
From: Moving forward through the in silico modeling of tuberculosis: a further step with UISS-TB
Outcome of digital patients treated with the second RUTI vaccine administration. Green line shows the average trend of cell populations, while the orange shaded area represents the standard deviation. One month after the end of antibiotic treatment, RUTI vaccine was administered accordingly to the clinical trial design followed by a second injection of RUTI (28 days after the first one). a The dynamics of AM that is comparable to the scenario observed after only one vaccine administration. Substantial increase in levels of TC, Th1, Th17 and IFNG is observed (b–e) compared to dynamics obtained with only one vaccine administration. For all the biological scenarios, simulation time has been set to 365 days (1 years) and digital patient have been challenged with MTB at day 15