Fig. 2
From: MADloy: robust detection of mosaic loss of chromosome Y from genotype-array-intensity data
Experimental mLOY validation. a LLR (black) and BAF (red) values of probes along chromosomes Y and X for an individual with positive mLOY status. Low values of LLR-Y are observed except for the PAR1 and PAR2 regions where a clear BAF split is observed. The BAF split is confirmed in the X chromosome. b MLPA validation of two individuals with mLOY with different cellularity content, compared with a normal individual (top). Two MLPA panels are shown for each individual, showing relative peak height (RPH) for probes in autosomes (A1, A2, A3) and in the X and Y chromosomes (Y1, Y2, Y3). Marking the peak for the chromosome X probe (dotted line), the figure shows a clear reduction in the RPH values of Y probes for the individuals with mLOY