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Table 3 Pathway analysis of REW-ISA obtained LFBs

From: REW-ISA: unveiling local functional blocks in epi-transcriptome profiling data via an RNA expression-weighted iterative signature algorithm

ID

Number of sites

Enrichment statistics

KEGG pathways

Apoptosis

DNA repair

Fatty acid metabolism

p53 pathway

UV response down

UV response Up

LFB1

4780

OR

0.9939

0.5541

0.2156

1.5781

2.2294

1.4360

p-value

1.0000

0.1891

0.0113

0.0655

0.0032

0.1887

FDR

1.0000

0.3219

0.0665

0.1573

0.0437

0.3219

LFB2

4834

OR

1.0623

0.5375

0.2092

1.7047

2.3044

1.2789

p-value

0.7558

0.1470

0.0114

0.0251

0.0019

0.4122

FDR

0.8245

0.2940

0.0665

0.1006

0.0437

0.5712

LFB3

4899

OR

0.9241

0.8954

0.3044

1.8062

2.2083

1.4464

p-value

1.0000

0.8738

0.0336

0.0129

0.0041

0.1967

FDR

1.0000

0.9253

0.1209

0.0665

0.0437

0.3219

LFB4

5440

OR

0.7568

0.8152

0.4260

1.4756

1.6945

1.3718

p-value

0.4760

0.6583

0.0531

0.0775

0.0453

0.2341

FDR

0.6119

0.7406

0.1469

0.1744

0.1469

0.3664

LFB5

5713

OR

0.7447

0.8027

0.4624

1.5126

1.4158

1.2249

p-value

0.4125

0.5729

0.0629

0.0526

0.1856

0.4756

FDR

0.5712

0.6874

0.1573

0.1469

0.3219

0.6119

LFB6

4714

OR

0.7329

0.7878

0.2251

1.5574

2.1795

1.3776

p-value

0.5174

0.6185

0.0162

0.0834

0.0049

0.3094

FDR

0.6423

0.7183

0.0729

0.1766

0.0437

0.4641

  1. The values with p-value less than 0.05 are shown in bold in the table
  2. OR stands for odds ratio; p-value is evaluated by Fisher’s exact test; and the FDR is calculated with BH method
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BMC Bioinformatics

ISSN: 1471-2105

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