REW-ISA: unveiling local functional blocks in epi-transcriptome profiling data via an RNA expression-weighted iterative signature algorithm

Table 5 Enzyme specificity analysis of REW-ISA obtained LFBs

ID	Number of sites	Enrichment statistics	Methyltransferase component
ID	Number of sites	Enrichment statistics	METTL3	METTL14	WTAP	KIAA1429
LFB1	4780	OR	2.5617	14.7698	9.8933	2.4626
		p-value	5.87E−184	0	0	2.71E−33
		FDR	7.83E−184	0	0	2.71E−33
LFB2	4834	OR	2.8308	15.4638	9.6866	2.6610
		p-value	1.28E−221	0	0	1.19E−40
		FDR	1.92E−221	0	0	1.25E−40
LFB3	4899	OR	3.2549	20.2677	12.1375	2.7250
		p-value	7.73E−278	0	0	1.80E−43
		FDR	1.24E−277	0	0	2.05E−43
LFB4	5440	OR	3.7806	17.8603	12.4793	2.9442
		p-value	0	0	0	4.22E−56
		FDR	0	0	0	5.33E−56
LFB5	5713	OR	4.0817	14.6430	12.9915	2.7716
		p-value	0	0	0	1.09E−50
		FDR	0	0	0	1.30E−50
LFB6	4714	OR	2.6572	18.1924	11.2583	2.7263
		p-value	3.71E−194	0	0	2.82E−42
		FDR	5.23E−194	0	0	3.07E−42

ISSN: 1471-2105