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Table 2 Predictors of LGG SPM pathway-level (C2 REACTOME) model and fitting results of Cox models

From: Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models

  Multivariable Cox model Univariable Cox model
Hazard ratios se(coef) p value Hazard ratios se(coef) p value
TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0.24 0.16 5.82E−19 0.54 0.08 4.03E−15
SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 1.79 0.17 7.24E−04 1.03 0.11 7.81E−01
G_ALPHA_Q_SIGNALLING_EVENTS 0.58 0.17 1.00E−03 0.62 0.14 5.09 E−04
PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS 2.64 0.31 1.58 E−03 0.87 0.08 7.50 E−02
DNA_REPLICATION 0.56 0.28 3.74 E−02 0.47 0.15 4.92 E−07
OLFCTORY_SIGNALING_PATHWAY 1.31 0.13 4.78E−02 0.94 0.12 6.05E−01
CELL_CYCLE_MITOTIC 0.95 0.21 8.14E−01 0.52 0.15 2.58E−05