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Table 2 Predictors of LGG SPM pathway-level (C2 REACTOME) model and fitting results of Cox models

From: Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models

 

Multivariable Cox model

Univariable Cox model

Hazard ratios

se(coef)

p value

Hazard ratios

se(coef)

p value

TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT

0.24

0.16

5.82E−19

0.54

0.08

4.03E−15

SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR

1.79

0.17

7.24E−04

1.03

0.11

7.81E−01

G_ALPHA_Q_SIGNALLING_EVENTS

0.58

0.17

1.00E−03

0.62

0.14

5.09 E−04

PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS

2.64

0.31

1.58 E−03

0.87

0.08

7.50 E−02

DNA_REPLICATION

0.56

0.28

3.74 E−02

0.47

0.15

4.92 E−07

OLFCTORY_SIGNALING_PATHWAY

1.31

0.13

4.78E−02

0.94

0.12

6.05E−01

CELL_CYCLE_MITOTIC

0.95

0.21

8.14E−01

0.52

0.15

2.58E−05