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Table 4 Predictors of LGG CNV pathway-level (Hallmark) model and fitting results of Cox models

From: Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models

  Multivariable Cox model Univariable Cox model
Hazard ratios se(coef) p value Hazard Ratios se(coef) p value
HYPOXIA 2.59E−03 1.73 5.79E−04 0.04 1.15 5.24E−03
MYC_TARGETS_V1 507.05 2.16 3.85E−03 858.29 1.27 9.38E−08
CHOLESTEROL_HOMEOSTASIS 13.96 1.08 1.49E−02 3.58 0.73 7.94E−02
PI3K_AKT_MTOR_SIGNALING 25.10 1.37 1.86E−02 2043.83 0.97 4.75E−15
OXIDATIVE_PHOSPHORYLATION 0.02 1.77 2.66E−02 0.03 1.34 7.16E−03
TGF_BETA_SIGNALING 6.40 0.96 5.33E−02 42.35 0.61 7.89E−10
EPITHELIAL_MESENCHYMAL_TRANSITION 11.00 1.79 1.79E−01 29.69 0.92 2.15E−04
IL2_STAT5_SIGNALING 5.36 1.52 2.69E−01 3.74 1.21 2.73E−01
KRAS_SIGNALING_UP 4.08 1.55 3.65E−01 151.12 0.86 5.18E−09
DNA_REPAIR 3.07 1.36 4.10E−01 15.60 1.08 1.12E−02
MYC_TARGETS_V2 0.42 1.19 4.70E−01 0.38 0.77 2.14E−01
ESTROGEN_RESPONSE_LATE 0.34 1.81 5.55E−01 0.01 1.18 1.35E−04
HEME_METABOLISM 0.39 1.80 6.01E−01 0.01 1.47 2.40E−03
HEDGEHOG_SIGNALING 0.75 0.70 6.82E−01 0.08 0.54 2.96E−06
ESTROGEN_RESPONSE_EARLY 1.31 1.96 8.90E−01 1.94E−03 0.90 3.78E−12
NOTCH_SIGNALING 1.04 0.75 9.54E−01 9.07 0.58 1.34E−04