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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Implementation of homology based and non-homology based computational methods for the identification and annotation of orphan enzymes: using Mycobacterium tuberculosis H37Rv as a case study

Fig. 3

Schematic representation of the ‘Hole Finding Protocol’ to identify local holes and chokepoints in an organism. The figure shows a flowchart of the workflow for the identification of 'local holes' and ‘chokepoints’ in an organism using an enzyme–enzyme dependency graph of all known metabolic reactions. ModEnzA [14] is a profile HMM-based method used to scan the proteome of a given organism for the accurate classification of its enzymes

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BMC Bioinformatics

ISSN: 1471-2105

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