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Table 2 Predicted candidate protein from M. tb using the ‘Hole filling protocol’

From: Implementation of homology based and non-homology based computational methods for the identification and annotation of orphan enzymes: using Mycobacterium tuberculosis H37Rv as a case study

Predicted missing enzyme Predicted candidate protein The rank of predicted candidate protein Predicted GO molecular function
(Precorrin-3B synthase)
Rv2064 1 4Fe-4S cluster binding/metal ion binding/oxidoreductase activity
(Precorrin-6A synthase)
Rv2847c 2 Precorrin 2 dehydrogenase activity
(Coprogen oxidase/ Porphyrin and chlorophyll metabolism)
Rv2388c 1 Coproporphyrinogen III oxidase
(3-alpha,7-alpha-dihydroxy-5-beta-cholestanate–CoA ligase)
Rv0459 1 Uncharacterized protein
Phosphoribosylformylglycinamidine cyclo-ligase
Rv0809 1 Phosphoribosylaminoimidazole synthetase
  1. The second column of the table shows the protein ID for the predicted candidate protein while the third column gives the rank of the prediction