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Table 2 Predicted candidate protein from M. tb using the ‘Hole filling protocol’

From: Implementation of homology based and non-homology based computational methods for the identification and annotation of orphan enzymes: using Mycobacterium tuberculosis H37Rv as a case study

Predicted missing enzyme

Predicted candidate protein

The rank of predicted candidate protein

Predicted GO molecular function

1.14.13.83

(Precorrin-3B synthase)

Rv2064

1

4Fe-4S cluster binding/metal ion binding/oxidoreductase activity

2.1.1.152

(Precorrin-6A synthase)

Rv2847c

2

Precorrin 2 dehydrogenase activity

1.3.3.3

(Coprogen oxidase/ Porphyrin and chlorophyll metabolism)

Rv2388c

1

Coproporphyrinogen III oxidase

6.2.1.28

(3-alpha,7-alpha-dihydroxy-5-beta-cholestanate–CoA ligase)

Rv0459

1

Uncharacterized protein

6.3.3.1

Phosphoribosylformylglycinamidine cyclo-ligase

Rv0809

1

Phosphoribosylaminoimidazole synthetase

  1. The second column of the table shows the protein ID for the predicted candidate protein while the third column gives the rank of the prediction