Fig. 4

Characterization of ASM around genes, repeats and histone modification peaks. a The distribution of ASM in different genomic regions. The X-axis shows the different cell lines. The Y-axis represents the calculated values obtained by dividing the percentage of ASM on the different elements by the percentage of the element length. b The overlap of ASM between different cell lines. The genome is partitioned into 2 kb-length bins; then, the number of ASM events is counted for each bin. The heat map shows the counts in all bins for different cell lines. c The distribution of ASM across the transcription start site (TSS). d The distribution of ASM across TSSs in expressed and unexpressed genes. We divided the genes into expressed and unexpressed genes. The figure shows the distribution of ASM on expressed genes (blue) and unexpressed genes (orange) (using the A549 cell line as an example). e The association between the ASM and allele genes. M-h and U-h indicate that the haplotype with high expression is methylated or unmethylated, respectively. M-n and U-n represent whether the haplotype without allele-specific expression is methylated or unmethylated, respectively. f The distribution of ASM in repeat regions. The red dashed line represents the center of the repeat regions. g The distribution of ASM across different histone modification peaks. The red dashed line represents the center of the peak regions