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Table 1 Comparison of read-based metagenomic annotation pipeline features

From: MetaLAFFA: a flexible, end-to-end, distributed computing-compatible metagenomic functional annotation pipeline

Feature MG-RAST SUPER-FOCUS eggNOG-mapper HUMAnN2 YAMP MetaLAFFA
Metagenomic functional annotation
Uses DIAMOND for read alignment
Read pre-processing    
Ortholog aggregation to broader functional categorizations
Available as a web service      
Native integration with distributed computing systems     
Automatic continuation from intermediate steps after interruption    
Convenient incorporation of new pipeline steps     
Universal single-copy gene-based abundance normalization via MUSiCC