Fig. 1
From: Inferring chromosome radial organization from Hi-C data
Determination of strong contact threshold and inference of radial CT distribution type. a Correlation of pairwise chromosomal strong interaction matrix obtained from original Hi-C with the matrix from corresponding randomly ligated Hi-C (solid lines) and chromosome length (dotted lines) at different values of \(h_{cut}\). b, d, f Pairwise inter-chromosomal strong interaction pattern matrix for GM12878 (b), BJ1-hTERT (d) and GM12878 simulated random ligation (f) Hi-C data respectively. Each entry of the matrix represents the total number of strong interacting bins between a pair of chromosomes. c, e, g 2D PCA projection of the pairwise inter-chromosomal strong interaction pattern matrices obtained from GM12878 (c), BJ1-hTERT (e) and GM12878 simulated random ligation (g) Hi-C data respectively. Correlations of the PC1 projection with gene density and chromosome length (in bp) are shown. Chromosomes are color coded based on their gene density (orange) or length (blue). Dark color = high gene density/large chromosome size and light color = low gene density/short chromosome length