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Fig. 2 | BMC Bioinformatics

Fig. 2

From: Inferring chromosome radial organization from Hi-C data

Fig. 2

Rearrangement of radial CT position in progeria and senescent cells compared to proliferating fibroblasts. a–c 2D PCA projection of the pairwise inter-chromosomal strong interaction pattern matrices obtained from WI38 proliferating (a), Hutchinson–Gilford progeria syndrome patient passage 19 (b) and WI38 senescent fibroblast (c) Hi-C data respectively. In progeria and senescent cells, chr10 (red color) and chr18 (green color) change their radial positions compared to the proliferating cells (chr10 change is not significant in progeria), while chrX maintains its peripheral position in all of the cases. d Radar plot representing the change in the radial order of the CTs in progeria and senescence compared to the proliferating condition. Chromosome radial positions are shown as ordered (ranked) in an increasing fashion from the center to periphery. Salient chromosomes discussed in the text are highlighted with red arrows

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