Fig. 5
From: Inferring chromosome radial organization from Hi-C data
Epithelial cells show different radial CT organization in a nuclear morphology dependent manner. a Pairwise inter-chromosomal strong interaction pattern matrix for MCF10A Hi-C data. b, e 2D PCA projection of the pairwise inter-chromosomal strong interaction pattern matrices obtained from MCF10A (b) and HMEC (e) Hi-C data respectively. c The radial distance profiles of 8 CTs (chr1, chr4, chr11, chr12, chr15, chr16, chr18 and chr21) for MCF10A obtained from the selected model cluster (# of models in the selected cluster: 48). Relative mean chromosome positions measured by microscopy shown below graph. d Correlation between predicted tuned CT distance from Hi-C data and microscopy imaging data for MCF10A cells. f The radial distance profiles of 4 CTs (chr18, chr19, chr1 and chr20) for both MCF10A and HMEC obtained from the respective selected model clusters (# of models in the selected clusters: for HMEC: 165)