Fig. 2From: Natrix: a Snakemake-based workflow for processing, clustering, and taxonomically assigning amplicon sequencing readsSchematic representation of the split-sample approach: extracted DNA from a single environmental sample is split and separately amplified and sequenced. The filtering rule compares the resulting read sets between two split-samples, filtering out all sequences that do not occur in both split-samples. Image adapted from Lange et al. [15]Back to article page