TY - JOUR AU - Corraliza-Gorjón, I. AU - Somovilla-Crespo, B. AU - Santamaria, S. AU - Garcia-Sanz, J. A. AU - Kremer, L. PY - 2017 DA - 2017// TI - New strategies using antibody combinations to increase cancer treatment effectiveness JO - Front Immunol VL - 8 UR - https://doi.org/10.3389/fimmu.2017.01804 DO - 10.3389/fimmu.2017.01804 ID - Corraliza-Gorjón2017 ER - TY - JOUR AU - Dalziel, M. AU - Beers, S. A. AU - Cragg, M. S. AU - Crispin, M. PY - 2018 DA - 2018// TI - Through the barricades: overcoming the barriers to effective antibody-based cancer therapeutics JO - Glycobiology VL - 28 UR - https://doi.org/10.1093/glycob/cwy043 DO - 10.1093/glycob/cwy043 ID - Dalziel2018 ER - TY - JOUR AU - Nizzero, S. AU - Ziemys, A. AU - Ferrari, M. PY - 2018 DA - 2018// TI - Transport barriers and oncophysics in cancer treatment JO - Trends Cancer VL - 4 UR - https://doi.org/10.1016/j.trecan.2018.02.008 DO - 10.1016/j.trecan.2018.02.008 ID - Nizzero2018 ER - TY - JOUR AU - Rosenblum, D. AU - Joshi, N. AU - Tao, W. AU - Karp, J. M. AU - Peer, D. PY - 2018 DA - 2018// TI - Progress and challenges towards targeted delivery of cancer therapeutics JO - Nat Commun VL - 9 UR - https://doi.org/10.1038/s41467-018-03705-y DO - 10.1038/s41467-018-03705-y ID - Rosenblum2018 ER - TY - JOUR AU - Jain, R. K. PY - 1990 DA - 1990// TI - Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors JO - Cancer Res VL - 50 ID - Jain1990 ER - TY - JOUR AU - Fuso Nerini, I. AU - Morosi, L. AU - Zucchetti, M. AU - Ballerini, A. AU - Giavazzi, R. AU - D’incalci, M. PY - 2014 DA - 2014// TI - Intratumor heterogeneity and its impact on drug distribution and sensitivity JO - Clin Pharmacol Ther VL - 96 UR - https://doi.org/10.1038/clpt.2014.105 DO - 10.1038/clpt.2014.105 ID - Fuso Nerini2014 ER - TY - JOUR AU - Kihara, T. AU - Ito, J. AU - Miyake, J. PY - 2013 DA - 2013// TI - Measurement of biomolecular diffusion in extracellular matrix condensed by fibroblasts using fluorescence correlation spectroscopy JO - PLoS ONE VL - 8 UR - https://doi.org/10.1371/journal.pone.0082382 DO - 10.1371/journal.pone.0082382 ID - Kihara2013 ER - TY - JOUR AU - Netti, P. A. AU - Berk, D. A. AU - Swartz, M. A. AU - Grodzinsky, A. J. AU - Jain, R. K. PY - 2000 DA - 2000// TI - Role of extracellular matrix assembly in interstitial transport in solid tumors JO - Cancer Res VL - 60 ID - Netti2000 ER - TY - JOUR AU - Davies, C. L. AU - Berk, D. AU - Pluen, A. AU - Jain, R. K. PY - 2002 DA - 2002// TI - Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells JO - Br J Cancer. VL - 86 UR - https://doi.org/10.1038/sj.bjc.6600270 DO - 10.1038/sj.bjc.6600270 ID - Davies2002 ER - TY - JOUR AU - Xie, H. AU - Jiao, Y. AU - Fan, Q. AU - Hai, M. AU - Yang, J. AU - Hu, Z. PY - 2018 DA - 2018// TI - Modeling three-dimensional invasive solid tumor growth in heterogeneous microenvironment under chemotherapy JO - PLoS ONE. VL - 13 UR - https://doi.org/10.1371/journal.pone.0206292 DO - 10.1371/journal.pone.0206292 ID - Xie2018 ER - TY - JOUR AU - Denisona, T. A. AU - Bae, Y. H. PY - 2012 DA - 2012// TI - Tumor heterogeneity and its implication to drug delivery JO - J Control Release VL - 164 UR - https://doi.org/10.1016/j.jconrel.2012.04.014 DO - 10.1016/j.jconrel.2012.04.014 ID - Denisona2012 ER - TY - JOUR AU - Karolak, A. AU - Rejniak, K. A. PY - 2019 DA - 2019// TI - Micropharmacology: an in silico approach for assessing drug efficacy within a tumor tissue JO - Bull Math Biol. VL - 81 UR - https://doi.org/10.1007/s11538-018-0402-x DO - 10.1007/s11538-018-0402-x ID - Karolak2019 ER - TY - JOUR AU - Karolak, A. AU - Estrella, V. C. AU - Huynh, A. S. AU - Chen, T. AU - Vagner, J. AU - Morse, D. L. PY - 2018 DA - 2018// TI - Targeting ligand specificity linked to tumor tissue topological heterogeneity via single-cell micro-pharmacological modeling JO - Sci Rep. VL - 8 UR - https://doi.org/10.1038/s41598-018-21883-z DO - 10.1038/s41598-018-21883-z ID - Karolak2018 ER - TY - JOUR AU - Ven, A. L. AU - Wu, M. AU - Lowengrub, J. AU - McDougall, S. R. AU - Chaplain, M. A. J. AU - Cristini, V. PY - 2012 DA - 2012// TI - Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors JO - AIP Adv. VL - 2 UR - https://doi.org/10.1063/1.3699060 DO - 10.1063/1.3699060 ID - Ven2012 ER - TY - JOUR AU - Rejniak, K. A. AU - Estrella, V. AU - Chen, T. AU - Cohen, A. S. AU - Lloyd, M. C. AU - Morse, D. L. PY - 2013 DA - 2013// TI - The role of tumor tissue architecture in treatment penetration and efficacy: an integrative study JO - Front Oncol. VL - 3 UR - https://doi.org/10.3389/fonc.2013.00111 DO - 10.3389/fonc.2013.00111 ID - Rejniak2013 ER - TY - JOUR AU - Groh, C. M. AU - Hubbard, M. E. AU - Jones, P. F. AU - Loadman, P. M. AU - Periasamy, N. AU - Sleeman, B. D. PY - 2014 DA - 2014// TI - Mathematical and computational models of drug transport in tumours JO - J R Soc Interface VL - 11 UR - https://doi.org/10.1098/rsif.2013.1173 DO - 10.1098/rsif.2013.1173 ID - Groh2014 ER - TY - JOUR AU - Minchinton, A. I. AU - Tannock, I. F. PY - 2006 DA - 2006// TI - Drug penetration in solid tumours JO - Nat Rev Cancer VL - 6 UR - https://doi.org/10.1038/nrc1893 DO - 10.1038/nrc1893 ID - Minchinton2006 ER - TY - JOUR AU - Erlanson, M. AU - Daniel-Szolgay, E. AU - Carlsson, J. PY - 1992 DA - 1992// TI - Relations between the penetration, binding and average concentration of cytostatic drugs in human tumour spheroids JO - Cancer Chemother Pharmacol VL - 29 UR - https://doi.org/10.1007/BF00686002 DO - 10.1007/BF00686002 ID - Erlanson1992 ER - TY - JOUR AU - Sutherland, R. AU - Buchegger, F. AU - Schreyer, M. AU - Vacca, A. AU - Mach, J. P. PY - 1987 DA - 1987// TI - Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies andtheir antigen binding fragments in human colon multicellular tumor spheroids JO - Cancer Res VL - 47 ID - Sutherland1987 ER - TY - JOUR AU - Lee, C. M. AU - Tannock, I. F. PY - 2010 DA - 2010// TI - The distribution of the therapeutic monoclonal antibodies cetuximab and trastuzumab within solid tumors JO - BMC Cancer VL - 10 UR - https://doi.org/10.1186/1471-2407-10-255 DO - 10.1186/1471-2407-10-255 ID - Lee2010 ER - TY - JOUR AU - Fischer, R. S. AU - Wu, Y. AU - Kanchanawong, P. AU - Shroff, H. AU - Waterman, C. M. PY - 2011 DA - 2011// TI - Microscopy in 3D: a biologist’s toolbox JO - Trends Cell Biol VL - 21 UR - https://doi.org/10.1016/j.tcb.2011.09.008 DO - 10.1016/j.tcb.2011.09.008 ID - Fischer2011 ER - TY - JOUR AU - Estrada, M. F. AU - Rebelo, S. P. AU - Davies, E. J. AU - Pinto, M. T. AU - Pereira, H. AU - Santo, V. E. PY - 2016 DA - 2016// TI - Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression JO - Biomaterials VL - 78 UR - https://doi.org/10.1016/j.biomaterials.2015.11.030 DO - 10.1016/j.biomaterials.2015.11.030 ID - Estrada2016 ER - TY - JOUR AU - Rebelo, S. P. AU - Pinto, C. AU - Martins, T. R. AU - Harrer, N. AU - Estrada, M. F. AU - Loza-Alvarez, P. PY - 2018 DA - 2018// TI - 3D-3-culture: a tool to unveil macrophage plasticity in the tumour microenvironment JO - Biomaterials VL - 163 UR - https://doi.org/10.1016/j.biomaterials.2018.02.030 DO - 10.1016/j.biomaterials.2018.02.030 ID - Rebelo2018 ER - TY - JOUR AU - Olarte, O. E. AU - Andilla, J. AU - Gualda, E. J. AU - Loza-Alvarez, P. PY - 2018 DA - 2018// TI - Light-sheet microscopy: a tutorial JO - Adv Opt Photonics VL - 10 UR - https://doi.org/10.1364/AOP.10.000111 DO - 10.1364/AOP.10.000111 ID - Olarte2018 ER - TY - JOUR AU - Tabatabai, M. AU - Williams, D. K. AU - Bursac, Z. PY - 2005 DA - 2005// TI - Hyperbolastic growth models: theory and application JO - Theor Biol Med Model. VL - 2 UR - https://doi.org/10.1186/1742-4682-2-14 DO - 10.1186/1742-4682-2-14 ID - Tabatabai2005 ER - TY - JOUR AU - Yin, X. AU - Goudriaan, J. AU - Lantinga, E. A. AU - Vos, J. AU - Spiertz, H. J. PY - 2003 DA - 2003// TI - A flexible sigmoid function of determinate growth JO - Ann Bot VL - 91 UR - https://doi.org/10.1093/aob/mcg029 DO - 10.1093/aob/mcg029 ID - Yin2003 ER - TY - JOUR AU - Praxmarer, M. AU - Sung, C. AU - Bungay, P. M. AU - Osdol, W. W. PY - 2001 DA - 2001// TI - Computational models of antibody-based tumor imaging and treatment protocols JO - Ann Biomed Eng. VL - 29 UR - https://doi.org/10.1114/1.1359453 DO - 10.1114/1.1359453 ID - Praxmarer2001 ER - TY - JOUR AU - Clauss, M. A. AU - Jain, R. K. PY - 1990 DA - 1990// TI - Interstitial transport of rabbit andsheep antibodies in normal and neoplastic tissues JO - Cancer Res VL - 50 ID - Clauss1990 ER - TY - JOUR AU - Berk, D. A. AU - Yuan, F. AU - Leunig, M. AU - Jain, R. K. PY - 1997 DA - 1997// TI - Direct in vivo measurement of targeted binding in a human tumor xenograft JO - Proc Natl Acad Sci USA VL - 94 UR - https://doi.org/10.1073/pnas.94.5.1785 DO - 10.1073/pnas.94.5.1785 ID - Berk1997 ER - TY - JOUR AU - Brown, E. B. AU - Boucher, Y. AU - Nasser, S. AU - Jain, R. K. PY - 2004 DA - 2004// TI - Measurement of macromolecular diffusion coefficients in human tumors JO - Microvasc Res VL - 67 UR - https://doi.org/10.1016/j.mvr.2004.02.001 DO - 10.1016/j.mvr.2004.02.001 ID - Brown2004 ER - TY - JOUR AU - Nissen, N. I. AU - Karsdal, M. AU - Willumsen, N. PY - 2019 DA - 2019// TI - Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology JO - J Exp Clin Cancer Res. VL - 38 UR - https://doi.org/10.1186/s13046-019-1110-6 DO - 10.1186/s13046-019-1110-6 ID - Nissen2019 ER - TY - CHAP AU - Jenkins, W. J. ED - Holland, H. D. ED - Turekian, K. K. PY - 2003 DA - 2003// TI - 6.08 - Tracers of ocean mixing BT - Treatise on Geochemistry PB - Pergamon CY - Oxford UR - https://doi.org/10.1016/B0-08-043751-6/06110-7 DO - 10.1016/B0-08-043751-6/06110-7 ID - Jenkins2003 ER - TY - JOUR AU - Guo, H. AU - Zhou, X. AU - Zhang, Y. AU - Gu, C. AU - Song, B. AU - Shi, H. PY - 2016 DA - 2016// TI - Kinetic analysis of a high-affinity antibody/antigen interaction performed by planar waveguide fluorescence immunosensor JO - RSC Adv VL - 6 UR - https://doi.org/10.1039/C6RA01073C DO - 10.1039/C6RA01073C ID - Guo2016 ER - TY - JOUR AU - Rhoden, J. J. AU - Dyas, G. L. AU - Wroblewski, V. J. PY - 2016 DA - 2016// TI - A modeling and experimental investigation of the effects of antigen density, binding affinity, and antigen expression ratio on bispecific antibody binding to cell surface targets JO - J Biol Chem VL - 291 UR - https://doi.org/10.1074/jbc.M116.714287 DO - 10.1074/jbc.M116.714287 ID - Rhoden2016 ER - TY - JOUR AU - Santo, V. E. AU - Estrada, M. F. AU - Rebelo, S. P. AU - Abreu, S. AU - Silva, I. AU - Pinto, C. PY - 2016 DA - 2016// TI - Adaptable stirred-tank culture strategies for large scale production of multicellular spheroid-based tumor cell models JO - J Biotechnol VL - 221 UR - https://doi.org/10.1016/j.jbiotec.2016.01.031 DO - 10.1016/j.jbiotec.2016.01.031 ID - Santo2016 ER - TY - JOUR AU - Gualda, E. J. AU - Pereira, H. AU - Vale, T. AU - Estrada, M. F. AU - Brito, C. AU - Moreno, N. PY - 2015 DA - 2015// TI - SPIM-fluid: open source light-sheet based platform for high-throughput imaging JO - Biomed Opt Express VL - 6 UR - https://doi.org/10.1364/BOE.6.004447 DO - 10.1364/BOE.6.004447 ID - Gualda2015 ER - TY - JOUR AU - Quartino, A. L. AU - Hillenbach, C. AU - Li, J. AU - Li, H. AU - Wada, R. D. AU - Visich, J. PY - 2016 DA - 2016// TI - Population pharmacokinetic and exposure-response analysis for trastuzumab administered using a subcutaneous “manual syringe” injection or intravenously in women with HER2-positive early breast cancer JO - Cancer Chemother Pharmacol VL - 77 UR - https://doi.org/10.1007/s00280-015-2922-5 DO - 10.1007/s00280-015-2922-5 ID - Quartino2016 ER - TY - JOUR AU - Luo, Y. AU - Li, W. AU - Jiang, Z. AU - Zhang, Q. AU - Wang, L. AU - Mao, Y. PY - 2019 DA - 2019// TI - Pharmacokinetics of pertuzumab administered concurrently with trastuzumab in Chinese patients with HER2-positive early breast cancer JO - Anticancer Drugs VL - 30 UR - https://doi.org/10.1097/CAD.0000000000000808 DO - 10.1097/CAD.0000000000000808 ID - Luo2019 ER - TY - JOUR AU - Dewhirst, M. W. AU - Secomb, T. W. AU - Carolina, N. PY - 2019 DA - 2019// TI - Transport of drugs from blood vessels to tumour tissue JO - Nat Rev Cancer VL - 17 UR - https://doi.org/10.1038/nrc.2017.93 DO - 10.1038/nrc.2017.93 ID - Dewhirst2019 ER - TY - JOUR AU - Zenuni, A. AU - Zhang, C. AU - Haeni, L. AU - Rothen-Rutishauser, B. AU - Scheffold, F. PY - 2019 DA - 2019// TI - Structure and sedimentation kinetics of dense suspensions of fibroblast cells JO - Chim Int J Chem VL - 73 UR - https://doi.org/10.2533/chimia.2019.43 DO - 10.2533/chimia.2019.43 ID - Zenuni2019 ER - TY - JOUR AU - Han, W. AU - Chen, S. AU - Yuan, W. AU - Fan, Q. AU - Tian, J. AU - Wang, X. PY - 2016 DA - 2016// TI - Oriented collagen fibers direct tumor cell intravasation JO - Proc Natl Acad Sci USA VL - 113 UR - https://doi.org/10.1073/pnas.1610347113 DO - 10.1073/pnas.1610347113 ID - Han2016 ER - TY - JOUR AU - Croce, M. A. AU - Boraldi, F. AU - Quaglino, D. AU - Tiozzo, R. AU - Pasquali-Ronchetti, I. PY - 2003 DA - 2003// TI - Hyaluronan uptake by adult human skin fibroblasts in vitro JO - Eur J Histochem VL - 47 UR - https://doi.org/10.4081/808 DO - 10.4081/808 ID - Croce2003 ER - TY - JOUR AU - Penno, M. B. AU - August, J. T. AU - Baylin, S. B. AU - Mabry, M. AU - Linnoila, R. I. AU - Lee, V. S. PY - 1994 DA - 1994// TI - Expression of CD44 in human lung tumors JO - Cancer Res VL - 54 ID - Penno1994 ER -