Fig. 3
From: Finding a suitable library size to call variants in RNA-Seq
SNVs sensitivity and expression of the recurrently mutated AML genes using the TCGA-LAML cohort. a Sensitivity in recovering mutations on recurrently mutated AML genes (Set2) using the TCGA-LAML cohort with callers default-filters. The size of the dots is proportional to the number of times a gene is mutated and genes were ordered by mutation load, with the most mutated genes at the top. Red dots corresponds to the results obtained with the initial library sizes and cyan dots using the downsampled libraries. b Expression distribution of recurrently mutated myeloid genes across the TCGA-LAML RNA-Seq samples used. The genes are reported in the same order as in a. Each dot corresponds to a sample and dots are coloured based on the percentage of times the variants detected on a sample are called by the callers using default-filters and the 40M libraries. A patient can harbour more than one mutation per gene. Horizontal violin plots are drawn below the dots