Fig. 4

Comparing the effects of resistance training per se on transcriptome profiles using different normalization models. Volcano plot identifies differentially expressed genes at Week 2 (a) and Week 12 (b) (adjusted P-values < 0.05 and Log2 fold-changes >|0.5|, filled circles). Bar-plots shows the total number of DE genes (horizontal bars) and sets exclusively found in each model or shared among models (vertical bars). The majority of differentially expressed genes were identified by all three normalization models, though the effective library-size model identified a larger number of genes with decreased expression (a)