Fig. 6

Inter-residue communication in V346D and I353D variants of MeV PMD. Communication blocks identified by COMMA2 are mapped on the average MD conformation for the wild type (a) and for variants bearing substitutions in the second half of the helices, I353D (b) and V346D (c). Those pathways are obtained by considering interactions involving side chains and pathways with length equal or greater than 4 and 8 residues. Residues known to be disordered in a context-dependent manner are shown by sticks. The \(CBs^{clique}\) identified by COMMA2 are colored in blue tones. d The disorder clique score (DCS) is reported for every CB clique of the wild type and variants of MeV PMD. e All direct communications between helices are shown on the structures. f The schematic representation, reports the number of direct pathways between helices in the first and second halves (numbers colored in black and red, respectively)