Table 3 Summary of the features used in this study

1

BsASA

Bound side-chain absolute ASA

2

BsRSA

Bound side-chain relative ASA

3

BtASA

Bound total absolute ASA

4

BtRSA

Bound total relative ASA

5

CsASA

Change in side-chain absolute ASA upon complexation

6

CsRSA

Change in side-chain relative ASA upon complexation

7

CtASA

Change in total absolute ASA upon complexation

8

CtRSA

Change in total relative ASA upon complexation

9

RsASA

Relative change in side-chain absolute ASA upon complexation

10

RsRSA

Relative change in side-chain relative ASA upon complexation

11

RtASA

Relative change in total absolute ASA upon complexation

12

RtRSA

Relative change in total relative ASA upon complexation

13

Eig

Eigenvector centrality index

14

Psi

IUPAC peptide backbone torsion angles PSI

15

HbCN

Half-sphere Cα-Cβ contact numbers

16

DN

The number of hydrogen bond donor residues

17

INP1-sASA

Interfacial neighborhood property 1 based on side-chain absolute ASA

18

INP1-sRSA

Interfacial neighborhood property 1 based on side-chain relative ASA

19

INP1-tASA

Interfacial neighborhood property 1 based on total absolute ASA

20

INP1-tRSA

Interfacial neighborhood property 1 based on total relative ASA

21

INP2-CsASA

Interfacial neighborhood property 2 based on change in side-chain absolute ASA upon complexation

22

INP2-CsRSA

Interfacial neighborhood property 2 based on change in side-chain relative ASA upon complexation

23

INP2-CtASA

Interfacial neighborhood property 2 based on change in total absolute ASA upon complexation

24

INP2-CtRSA

Interfacial neighborhood property 2 based on change in total relative ASA upon complexation